My wife has a 2020 sequoia platinum and she loves it. Had a 4Runner before she loved. Only reason we upgraded I was too fat pre heart attack, so I wanted more room to move the seat back. 4Runner isn’t the best with 2 car seats but based off her age I think you’re safe there. I love the sequoia way better than the 4Runner as it has selectable 4wd unlike 4Runner. So turning radius is way better as well. Biggest gripe with it is smaller gas tank size.

I have a Lexus GX460 for a work vehicle. It is extremely smooth and comfortable. Even AWD and it’s still great and turns really well. Better than the 4Runner. Either one would be a solid choice. If you don’t need 3rd row with toting grandkids or big family around I’d suggest GX, although not much difference in mpg or turning. GX does require premium fuel so there’s that added cost